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    Visit : Total Views: 114Word Count: 534See All articles From Author

    Research Method:

     

    Quantitative determination by contrasting HBV-DNA of cases before and after the treatment.

     

    Number of cases: 25 (n)

     

    Case Selection: Between the age of 16 and 65, in accordance with the diagnosis standards pf chronic Hepatitis B, with negative e antigen and positive e antibody Cheap NFL Jerseys Free Shipping , HBV-DNA > 1?104 cpmL.

     

    Detection Method: All the blood samples are detected by Sichuan Clinical Detection Center; PCR-ELISA quantitative determination is used within detection range of 1?104 - 1?107-8, HBV-DNA, unit of measurement is cpmL.

     

    Direction Plan: one suppository provided by Vigconic (International) Ltd. Bid. The course of treatment is six months, the tracing observation after withdrawal lasts six months.

     

    Observation index:

     

     

     

    HBV-DNA response after the treatment.

     

    Lasting HBV-DNA response (six months after withdrawal).

     

     

     

    Criterion of Therapeutic Effect:

     

     

     

    If HBV-DNA volume 1?104 cpmL: 425 (16%)

     

    Lasting response:

     

     

     

    HBV-DNA volume 1?104 cpmL: 225 (8%)

     

    Among the results of lasting response Cheap NFL Jerseys Wholesale , 16 blood serum samples are detected through fluorimetric quantitative determination PCR by the instruments of , H-7700 in the second attached hospital of Guangzhou Medical College. The result is in accordance with that in Sichuan Clinical Testing Center. (8 cases among it < 1?102 cpmL). The testing range of this testing method is 1?102 - 1?107-8 cpmL.

     

    Conclusion

     

    The reason for the repeatedly abnormal liver function of Chronic Hepatitis B (CHB) patients lies in the repeatedly duplication of HBV after infection, which leads to fibrosis of liver, then cirrhosis and liver cancer. It is commonly accepted that if CHB shows the transformation of HBeAgAnti-HBe Cheap NFL Jerseys From China , HBV-DNA becoming negative, liver function returning to normal state, the disease is relieved.

     

    However, parts of patients with the transformation of HBeAgAnti-HBe still remain positive in HBV-DNA and the pathological change in the liver continues. Because HBV-DNA occurs promoter mutation in the anterior C section (1896 necleoside G-A variation) or in the C section (1762 nucleoside T variation Cheap NFL Jerseys China , 1764 G-A variation), HBeAg cannot come into being. Therefore, the HBeAg in the patient's blood cannot be detected, while the virus can keep on duplicating and fixing itself. Through sequential assay of nucleic acid Cheap NFL Jerseys , it proves that promoter mutation appears in 30%-60% of HBeAg negative Chronic Hepatitis B (CHB) in the anterior C section or in the C section.

     

    In some provinces and cities of the People of China, the percentage of promoter mutation appears in HBeAg negative Chronic Hepatitis B (CHB) in the anterior C section or in the C section is from 17.6% to 78.9%. Eight out of the 25 cases of our observation go through the sequential assay of nucleic acid carried out by the Department of Mi. Cheap Jerseys From China   Cheap Authentic Jerseys   Cheap NBA Jerseys China   Cheap Authentic MLB Jerseys   Cheap Jerseys Online   Wholesale Jerseys China Wholesale   Wholesale Jerseys Supply   Cheap Jerseys   Wholesale Hockey Jerseys China   Wholesale Basketball Jerseys Free Shipping